| 1. Controlled Drug Delivery System |
 |
Delivery of therapeutic agents into a targeted area of the body at continuous
and controlled rates over a period of weeks or months |
|
Getting pharmaceuticals to targeted tissue or organ sites is important to
successful regenerative therapeutics.
Polymers, physiologically inert and biodegradable polymers from both
natural and synthetic sources, are essential for targeted delivery or timed
release of drugs in chosen herapies.
Drug delivery vehicles being formulated in our lab are injectable microspheres,
topical liposomes, implantable hydrogels and devices. |
|
 |
 |
 |
| 2. Bio-Organic Composite Scaffold fabrication |
|
Fabrication of functional scaffolds for promoting the tissue regeneration such as bone, nerve, vessel formation using growth factors and bio-organic hybrid materials |
|
We are working on fabrication of three dimensional polymer scaffolds by using natural or biological molecules combined with synthetic polymeric materials for improving cell viability, unction and enhanced tissue regeneration.
We use growth factors such as BMP for enhanced bone regeneration, VEGF for new blood essel formation and nerve growth factor (NGF) for promoting reinnervation of tissues in multiple combinations into the scaffold system by using controlled release technologies. |
|
 |
|
|
| 3. Electrospinning technology |
|
Electrospinning technology offers
the
potential for ontrolling
composition,
structure and
mechanical roperties of
iomaterials. sing this technique,
we
have fabricated various lectrospun
scaffolds for vascular grafts or
vessel
conduits, bone scaffolds, wound
dressings and drug
delivery agents. |
|
  |
|
|
| 4. Cell encapsulation for cell therapy |
|
We are working on micro-encapsulation of different healthy cell types for delivery as therapeutic products to replace cells dysfunctional due to disease (e.g. pain, cancer, diabetes). Cell encapsulation with polymeric membranes is used for cell therapy by enclosing a wide range of cells, permitting the entry of nutrients and oxygen and the exit of therapeutic protein products, thus providing immunoisolation. |
|
 |
|
 |
|
|
| 5. Integration of nanotechnology for imaging and drug targeting |
|
We are working on formulating new safe and effective nanoparticles for vastly improving the ability of detection and therapy of a cancer. We formulated a prostate cancer specific nanoparticle that is composed of a polymeric nano-particle with an antibody for prostate specific membrane antigen and a contrast agent utilized in MR imaging. The use of polymeric nanocomposites permitted a high density of prostate specific antibody and gadolinium in a targeted tumor space generated by cancer cells, thereby enhanced the sensitivity of target imaging and enabled the delayed clearance from the tumor site in vitro and in vivo. |
|
  |
|
|
|
홈> Research 
